Laronidase is used to treat a certain rare genetic
problem (mucopolysaccharidosis-MPS I). It works by replacing a certain
natural substance (lysosomal enzyme) that is missing in people with this
genetic problem. This medication improves lung function and how far you can
walk. Laronidase is not a cure and treatment must be continued for
life.
Read the Patient Information Leaflet if available from
your pharmacist before you start using laronidase and each time you get a
refill. If you have any questions, ask your doctor or
pharmacist.
This medication is given by injection into a vein as
directed by your doctor, usually every week. The injection is given by a
health care professional, usually over 3 to 4 hours. The dosage is based on
your medical condition, weight, and response to treatment.
Infusion reactions may happen during the infusion of
this drug. Your doctor may prescribe other medications 60 minutes before
each treatment to help prevent these side effects. Tell your doctor right
away if you have any symptoms of infusion reactions such as flushing,
fever, headache, or abdominal pain. Your doctor may slow down or stop your
treatment for some time. See also Warning section.
Use this medication regularly to get the most benefit
from it. To help you remember, mark your calendar with a
reminder.
Tell your doctor if your condition gets
worse.
See also How to Use section and Warning
section.
Cold symptoms (such as stuffy/runny nose, cough) may
occur. If any of these effects last or get worse, tell your doctor or
pharmacist promptly.
Remember that this medication has been prescribed
because your doctor has judged that the benefit to you is greater than the
risk of side effects. Many people using this medication do not have serious
side effects.
This is not a complete list of possible side effects. If
you notice other effects not listed above, contact your doctor or
pharmacist.
In the US - Call your doctor for medical advice about side effects.
You may report side effects to FDA at 1-800-FDA-1088 or at
www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about
side effects. You may report side effects to Health Canada at
1-866-234-2345.
See Warning section.
Before using laronidase, tell your doctor or pharmacist
if you are allergic to it; or if you have any other allergies. This product
may contain inactive ingredients, which can cause allergic reactions or
other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or
pharmacist your medical history.
Before having surgery, tell your doctor or dentist about
all the products you use (including prescription drugs, nonprescription
drugs, and herbal products).
During pregnancy, this medication should be used only
when clearly needed. Discuss the risks and benefits with your
doctor.
It is unknown if this medication passes into breast
milk. Consult your doctor before breastfeeding.
Drug interactions may change how your medications work
or increase your risk for serious side effects. This document does not
contain all possible drug interactions. Keep a list of all the products you
use (including prescription/nonprescription drugs and herbal products) and
share it with your doctor and pharmacist. Do not start, stop, or change the
dosage of any medicines without your doctor's approval.
If someone has overdosed and has serious symptoms such
as passing out or trouble breathing, call 911. Otherwise, call a poison
control center right away. US residents can call 1-800-222-1222. Canada
residents can call 1-844-764-7669.
Lab and/or medical tests (such as lung function, urine
tests, immunoglobulin levels) should be done before you start using this
medication and while you are using it. Keep all medical and lab
appointments. Consult your doctor for more details.
It is important to get each dose of this medication as
scheduled. If you miss a dose, ask your doctor or pharmacist right away for
a new dosing schedule.
Not applicable. This medication is given in a hospital
or clinic and will not be stored at home.
