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Sebelipase Alfa - Injection

Pronunciation: SE-be-LYE-pase AL-fa

Common Brand Name(s): Kanuma

Important: How To Use This Information

This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Uses

This medication is used to treat a certain rare genetic problem (lysosomal acid lipase deficiency LAL-D). Sebelipase alfa replaces a certain natural substance (an enzyme called lysosomal acid lipase) that is missing in people with LAL-D. This helps the body to breakdown fats. High fat levels can lead to liver damage or high blood cholesterol levels.

How To Use

Read the Patient Information Leaflet if available from your pharmacist before you start using sebelipase alfa and each time you get an infusion. If you have any questions, ask your doctor or pharmacist.

This medication is given by injection into a vein as directed by your doctor, usually once every week or once every other week. The injection is given by a health care professional, usually over 2 hours. The dosage is based on your medical condition, age, weight, and response to treatment.

Infusion reactions or serious allergic reactions may happen while you are receiving sebelipase alfa. A health care professional will carefully monitor you during and after your infusion. Get medical help right away if you have any symptoms of infusion reactions such as chest pain, fast heartbeat, stomach pain, mental/mood changes, fever, chills, or nausea. Your doctor may slow down or stop your treatment for some time if you get serious side effects. Your doctor may also prescribe other medications before each treatment to help prevent these side effects. Carefully follow your doctor's directions for all of your medications.

Use this medication regularly to get the most benefit from it. To help you remember, mark the days on a calendar you need to receive this medication.

Tell your doctor if your condition gets worse.

Side Effects

Precautions

Before using sebelipase alfa, tell your doctor or pharmacist if you are allergic to it; or to egg products; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This drug may rarely make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Alberta residents can call PADIS (Poison and Drug Information Service) 24 hours a day at 1-800-332-1414. Canada residents can call a provincial poison control center.

Notes

Lab and/or medical tests (such as cholesterol/triglyceride levels, liver function, height, weight) should be done before you start using this medication and while you are using it. Keep all medical and lab appointments. Consult your doctor for more details.

Missed Dose

It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule.

If you have questions about missing a dose or you don't have more medication, contact your healthcare provider or pharmacist.

Storage

Not applicable. This medication is given in a hospital or clinic and will not be stored at home.

Information last revised April 2023.

Selected from data included with permission and copyright by First DataBank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

Conditions of Use: The information in this database is intended to supplement, not substitute for the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The display and use of this drug information is subject to express Terms of Use.

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